Over-the-counter use

Minor trauma wounds:

Clean the wound surface with saline or water, wait until bleeding stops, and apply CURIOSIN^® (zinc hyaluronan) in a thin layer (1mm of the Gel or 1 drop/cm² of the Fluid) to the entire wound surface. Covering the wound is optional, you may let CURIOSIN^® dry on the surface or may cover the wound with a primary non-stick gauze dressing and a self-adhesive bandage.
CURIOSIN^® can be used repeatedly.

Minor burns:

Cool the burnt surface with running cold water and apply CURIOSIN^® as instructed above.

Mild-to-moderate form of acne vulgaris (spots, pimples):

After cleansing gently rub CURIOSIN^® into the affected skin area twice daily (rub gently until completely absorbed to avoid dried remnants of the gel on the skin).

 

Use under the supervision of a healthcare professional:

A health care professional should be consulted prior to the first use of and for the duration of the treatment with CURIOSIN^® for chronic wounds. The treatment of chronic wounds such as leg ulcers, pressure ulcers, diabetic ulcers should be under the supervision of a healthcare professional who will instruct on the other elements of the complex therapy of the underlying disease (e.g.: compression bandage, pressure relief measures, blood glucose control, infection control).

• complete debridement (if needed), clean the skin area to be treated by gently rinsing with saline or water and wait until bleeding stops.
• apply CURIOSIN^® as a continuous thin layer (1mm of the Gel or 1 drop/cm² of the Fluid) to the entire compromised skin area(s) (if necessary, a clean application aid e.g. a cotton swab or a tongue depressor can be used)
• once CURIOSIN^® has been applied, you may cover the wound with a non-stick gauze dressing and wrap it over with a self-adhesive bandage
• repeat the process of wound cleansing, applying CURIOSIN^® and bandaging daily, in the case of heavily exuding wounds twice a day 

What undesirable effects may CURIOSIN^® have?

In some case local hypersensitivity (allergic reaction) may emerge.The following symptoms may occasionally occur at the beginning of use: redness, mild transient stinging or burning sensations, and local pain.
The following conditions were reported very rarely during clinical trials: hypergranulation and partial necrosis found only in a very limited area of the wound bed, but the causal relationship to CURIOSIN^® therapy has not been established.